| Event | Time | Date | Name | Meet | History |
|---|---|---|---|---|---|
| 50 Free | 23.14 | Feb. 12, 2015 | Kirsten Slaughter | College Conference of Illinois & Wisconsin Championships | |
| 100 Free | 51.14 | Feb. 14, 2015 | Kirsten Slaughter | College Conference of Illinois & Wisconsin Championships | |
| 200 Free | 1:51.65 | Feb. 10, 2017 | Meg Stanley | College Conference of Illinois & Wisconsin Championships | |
| 500 Free | 4:50.76 | March 15, 2017 | Meg Stanley | NCAA Division III Championships | |
| 1000 Free | 10:31.88 | Jan. 30, 2016 | Meg Stanley | Franklin vs. Illinois Wesleyan | |
| 1650 Free | 16:41.93 | March 18, 2017 | Meg Stanley | NCAA Division III Championships | |
| 50 Back | 26.32 | Feb. 18, 2011 | Andrea Peterson | College Conference of Illinois & Wisconsin Championships | |
| 100 Back | 55.74 | Feb. 18, 2011 | Andrea Peterson | College Conference of Illinois & Wisconsin Championships | |
| 200 Back | 2:01.14 | Feb. 19, 2011 | Andrea Peterson | College Conference of Illinois & Wisconsin Championships | |
| 50 Breast | 32.08 | Oct. 13, 2023 | Hadley Fudge | Lewis vs Illinois Wesleyan | |
| 100 Breast | 1:04.60 | Feb. 18, 2022 | Hadley Fudge | CCIW Championships | |
| 200 Breast | 2:20.48 | Feb. 22, 2020 | Lauren Feddersen | College Conference of Illinois & Wisconsin Championships | |
| 50 Fly | 28.08 | March 1, 2021 | Jackie Rae Kelch | Titan Cup | |
| 100 Fly | 55.62 | Feb. 21, 2020 | Ellen Gilbert | College Conference of Illinois & Wisconsin Championships | |
| 200 Fly | 2:01.65 | March 22, 2013 | Katie McHugh | NCAA Division III Championships | |
| 100 IM | 1:01.63 | Oct. 22, 2021 | Hadley Fudge | Lewis vs. Illinois Wesleyan vs. UMSL | |
| 200 IM | 2:06.89 | Feb. 16, 2023 | Hadley Fudge | CCIW Championships | |
| 400 IM | 4:34.29 | March 18, 2002 | Kathy Carroll | - | |
| 200 Free Relay | 1:34.59 | Feb. 12, 2016 | Slaughter, Stanley, Hoecker, Cheng | College Conference of Illinois & Wisconsin Championships | |
| 400 Free Relay | 3:29.20 | Feb. 16, 2019 | Gilbert, Wong, Saucedo, Cheng | College Conference of Illinois & Wisconsin Championships | |
| 800 Free Relay | 7:34.42 | March 18, 2016 | Cheng, Stanley, Hoecker, Slaughter | NCAA Division III Championships | |
| 200 Medley Relay | 1:46.62 | Feb. 18, 2012 | College Conference of Illinois & Wisconsin Championships | ||
| 200 Medley Relay | 1:46.62 | Feb. 18, 2012 | Peterson, Egan, McHugh, Lugg | College Conference of Illinois & Wisconsin Championships | |
| 400 Medley Relay | 3:51.57 | Feb. 17, 2011 | Peterson, Egan, McHugh, Lugg | College Conference of Illinois & Wisconsin Championships |
