| Time | Date | Name | Meet |
|---|---|---|---|
| 4:15.67 | March 21, 2024 | Neely Burns | NCAA Division III Championship |
| 4:18.50 | March 16, 2023 | Neely Burns | NCAA Division III Championship |
| 4:21.76 | Feb. 10, 2023 | Neely Burns | Southern Collegiate Athletic Conference Championships |
| 4:22.01 | Nov. 19, 2022 | Neely Burns | Tiger Invitational |
| 4:23.46 | Nov. 4, 2022 | Neely Burns | Chicago D3 Shootout |
| 4:27.40 | Feb. 14, 2014 | Kara Beauchamp | Southern Collegiate Athletic Conference Championships |
| 4:28.49 | Feb. 15, 2013 | Kara Beauchamp | Southern Collegiate Athletic Conference Championships |
| 4:33.62 | Feb. 13, 2013 | Melanie Gustafson | Southern Collegiate Athletic Conference Championships |
| 4:36.61 | Feb. 19, 2010 | Lisa Tucci | Southern Collegiate Athletic Conference Championships |
| 4:42.00 | Nov. 21, 2009 | Lisa Tucci | Trinity Western Shootout |
