| Name | Time | Date | Meet |
|---|---|---|---|
| Garrison Herfel | 49.43 | Feb. 5, 2021 | Centre First chance Meet |
| Noah Martin | 49.53 | Feb. 10, 2017 | 2017 Southern Athletic Association Championships |
| Noah Martin | 50.17 | Feb. 13, 2015 | 2015 Southern Athletic Association Championships |
| Jess Pritchett | 51.43 | Feb. 15, 2014 | 2014 Southern Athletic Association Championships |
| Aaron Edwards | 52.78 | Feb. 18, 2011 | Southern Collegiate Athletic Conference Championships |
| Aaron Edwards | 52.98 | Feb. 19, 2010 | Southern Collegiate Athletic Conference Championships |
| Hunter Owen | 53.57 | Oct. 17, 2008 | Butler, Centre @ IUPUI |
