| Time | Date | Name | Meet |
|---|---|---|---|
| 2:09.67 | March 2, 2019 | Marie-Claire Schillinger | Conference USA Championships |
| 2:10.42 | Feb. 24, 2018 | Marie-Claire Schillinger | Conference USA Championships |
| 2:10.84 | Nov. 18, 2017 | Marie-Claire Schillinger | Phil Hansel Invitational |
| 2:10.92 | Feb. 25, 2017 | Marie-Claire Schillinger | Conference USA Championships |
| 2:11.67 | Nov. 20, 2016 | Marie-Claire Schillinger | Phill Hansel Invitational |
| 2:11.84 | Feb. 27, 2016 | Marie-Claire Schillinger | Conference USA Championships |
| 2:13.46 | March 1, 2014 | Rachel Moody | Conference USA Championships |
| 2:15.27 | Jan. 31, 2014 | Rachel Moody | Houston vs. Louisiana State, Rice, Tulane |
| 2:16.57 | Nov. 23, 2013 | Rachel Moody | Phill Hansel Invitational |
| 2:17.31 | Feb. 27, 2010 | Alexandria O'Brien | Conference USA Championships |
| 2:22.05 | Jan. 29, 2010 | Pam Zelnick | Houston vs. Louisiana State, Rice, Tulane |
| 2:22.17 | Oct. 24, 2009 | Alexandria O'Brien | SMU Women's Classic |
| 2:22.87 | Feb. 25, 2009 | Alexandria O'Brien | Conference USA Championships - Day One - Finals |
| 2:23.35 | Nov. 6, 2008 | Ashten Ackerman | Rice @New Mexico State |
| 2:24.95 | Oct. 10, 2008 | Ashten Ackerman | North Texas & Rice @Texas A&M |
