| Time | Date | Name | Meet |
|---|---|---|---|
| 4:28.34 | Feb. 14, 2020 | Gwyn Ledrick | Ohio Athletic Conference Championships |
| 4:29.99 | Feb. 16, 2018 | Carly Adams | Ohio Athletic Conference Championships |
| 4:34.20 | Feb. 17, 2017 | Carly Adams | Ohio Athletic Conference Championships |
| 4:34.91 | Feb. 19, 2016 | Carly Adams | Ohio Athletic Conference Championships |
| 4:38.25 | Dec. 6, 2015 | Carly Adams | Fredonia Invitational |
| 4:40.71 | Feb. 20, 2015 | Carly Adams | Ohio Athletic Conference Championships |
| 4:42.71 | Dec. 7, 2014 | Carly Adams | Transylvania Invitational |
| 4:46.48 | Nov. 1, 2014 | Carly Adams | Case Western vs. John Carroll |
| 4:50.98 | Feb. 17, 2012 | Brittany Krauth | Ohio Athletic Conference Championships |
| 4:53.08 | Feb. 18, 2011 | Brittany Krauth | Ohio Athletic Conference Championships |
| 4:53.49 | Nov. 12, 2010 | Julia Adams | Case Western Reserve Veale Classic |
| 4:54.17 | Feb. 19, 2010 | Brittany Krauth | Ohio Athletic Conference Championships |
| 4:54.64 | Nov. 13, 2009 | Julia Adams | Veale Classic |
| 4:59.80 | Oct. 25, 2008 | Heidi Benson | Ohio Northern @John Carroll |
