| Time | Date | Name | Meet |
|---|---|---|---|
| 3:58.23 | March 22, 2019 | Sydney Pickrem | NCAA Division I Womens Championships |
| 3:59.05 | March 16, 2018 | Sydney Pickrem | NCAA Division I Womens Championships |
| 3:59.30 | Feb. 16, 2018 | Sydney Pickrem | Southeastern Conference Championships |
| 3:59.36 | March 17, 2017 | Sydney Pickrem | NCAA Division I Womens Championships |
| 4:01.56 | Nov. 16, 2012 | Cammile Adams | Phil Hansel Invitational |
| 4:05.30 | March 18, 2011 | Sarah Henry | NCAA Division I Womens Championships |
| 4:05.48 | Feb. 25, 2011 | Sarah Henry | Big 12 Conference Championships |
| 4:06.66 | Nov. 20, 2010 | Sarah Henry | Georgia Tech Invitational - Women |
| 4:11.02 | March 21, 2008 | Melissa Hain | NCAA Division I Womens Championships |
| 4:13.28 | March 9, 2007 | Melissa Hain | NCAA Division I Womens Championships |
| 4:20.11 | Feb. 28, 2002 | Alex Baldree | USA Swimming Sectionals - College Station |
