| Time | Date | Name | Meet |
|---|---|---|---|
| 51.61 | Feb. 18, 2022 | Josh Bottelberghe | Atlantic Coast Championships |
| 51.88 | Nov. 19, 2021 | Josh Bottelberghe | Ohio State Invitational |
| 52.25 | March 1, 2017 | Trent Jackson | Atlantic Coast Championships (M) |
| 52.50 | March 27, 2015 | Zach Stephens | NCAA Division I Mens Championships |
| 52.54 | Dec. 6, 2014 | Zach Stephens | Hawkeye Invitational |
| 52.59 | Feb. 28, 2014 | Zach Stephens | Atlantic Coast Conference Championships (M) |
| 52.95 | March 1, 2013 | Chris Johnson | Big East Conference Championships |
| 53.75 | Feb. 18, 2011 | Chris Johnson | Big East Conference Championships |
| 55.55 | Jan. 29, 2011 | Chris Johnson | Shamrock Invite |
| 55.63 | Feb. 19, 2010 | Chris Johnson | Big East Championships |
| 56.35 | Feb. 20, 2009 | Joe Raycroft | Big East Championships - Day Three - Finals |
