| Time | Date | Name | Meet |
|---|---|---|---|
| 4:18.16 | March 3, 2016 | Till Pallmann/Gary Brinkman | - |
| 4:24.98 | Nov. 21, 2014 | Till Pallmann | Louisville Invitational |
| 4:26.53 | Nov. 21, 2013 | Till Pallmann | Missouri Invitational |
| 4:28.27 | Nov. 29, 2012 | Till Pallmann | USA Swimming Winter Nationals |
| 4:29.11 | March 1, 2012 | Csaba Gercsak | Mid-American Conference Mens Championships |
| 4:29.48 | March 3, 2011 | Matthew Parsons | Mid-American Conference Mens Championships |
| 4:31.42 | Nov. 19, 2010 | Matt Kruse | Purdue Invitational |
| 4:33.90 | Dec. 4, 2009 | El Badrawi | Missouri Invitational |
| 4:39.85 | Nov. 14, 2009 | El Badrawi | Missouri vs. Southern Illinois |
| 4:40.54 | Oct. 30, 2009 | Matthew Parsons | Southern Illinois vs. Washington (Mo) |
| 4:42.10 | Oct. 17, 2009 | El Badrawi | Kentucky vs. Arkansas, Cumberland, Southern Illinois |
| 4:44.07 | Oct. 10, 2009 | Matt Kruse | Southern Illinois vs. Miami-OH |
| 4:47.44 | Feb. 19, 2009 | Ray Sophie | Sun Belt Conference Championships - Day One - Finals |
