| Time | Date | Name | Meet |
|---|---|---|---|
| 3:38.56 | Feb. 23, 2024 | Pulido, Robertson, Padron Salazar, Hernandez Barradas | Missouri Valley Conference Championships |
| 3:40.46 | Feb. 2, 2024 | Pulido, Herron, Padron Salazar, Hernandez Barradas | UIC vs. Southern Illinois, Valpo |
| 3:40.50 | Nov. 16, 2023 | Pulido, Herron, Atkinson, Zhukova | Purdue Invitational |
| 3:41.26 | Oct. 9, 2021 | Pulido, Zaborska, Rau, Forbord | Southern Illinois vs. Missouri |
| 3:41.84 | Feb. 21, 2020 | Romero Endolz, Vogt, Naude, Forbord | Missouri Valley Conference Championships |
| 3:45.31 | Feb. 17, 2017 | James, Carver, Brazeau, Handley | Missouri Valley Conference Championships |
| 3:46.24 | Nov. 18, 2016 | James, Parsons, Brazeau, Handley | Louisville Invitational |
| 3:47.04 | Oct. 1, 2016 | James, Tatigian, Hauer, Fuller | Evansville vs. Southern Illinois |
| 3:47.77 | Feb. 19, 2016 | James, Tatigian, Brazeau, Handley | Missouri Valley Conference Championships |
| 3:48.07 | Feb. 20, 2015 | James, Tatigian, Ksarjian, Johnson | Missouri Valley Conference Championships |
| 3:48.42 | Feb. 16, 2012 | Castro, Geppert, Davies, Benitez | Missouri Valley Conference Championships |
| 3:49.76 | Feb. 11, 2010 | Dvorak, Geppert, Groome, Mattsson | Missouri Valley Conference Championships |
| 3:49.82 | Feb. 12, 2009 | Missouri Valley Conference Championships - Day One - Finals | |
| 3:53.54 | Dec. 5, 2008 | Mizzou Invitational |
