| Time | Date | Name | Meet |
|---|---|---|---|
| 4:18.55 | Feb. 28, 2019 | Din Selmanovic | American Athletic Conference Championships |
| 4:20.01 | Feb. 15, 2018 | Din Selmanovic | American Conference Championships |
| 4:20.37 | March 23, 2017 | Christopher Bready | NCAA Division I Mens Championships |
| 4:20.44 | Feb. 16, 2017 | Din Selmanovic | American Conference Championships |
| 4:23.24 | Nov. 17, 2016 | Christopher Bready | Bearcat Midseason Invitational |
| 4:25.49 | Feb. 18, 2016 | Christopher Bready | American Conference Championships |
| 4:26.01 | Dec. 3, 2015 | Christopher Bready | Hoosierland Invitational |
| 4:26.56 | Dec. 4, 2014 | Eitan Holder | Miami Invitational |
| 4:26.65 | Feb. 17, 2011 | Steven Cunningham | Big East Conference Championships |
| 4:28.30 | Feb. 19, 2009 | Nathan Williams | Big East Championships - Day Two - Finals |
| 4:30.11 | Dec. 6, 2008 | Nathan Williams | Miami Invitational |
| 4:40.58 | Nov. 15, 2008 | Nathan Williams | Pittsburgh @Cincinnati |
