| Time | Date | Name | Meet |
|---|---|---|---|
| 3:18.15 | Feb. 24, 2024 | Hernandez, Wright, Tighe, Rickert | Atlantic 10 Championships |
| 3:19.22 | Feb. 18, 2023 | Rickert, Wright, Hernandez, SCHAAL | Atlantic 10 Conference Championships |
| 3:21.16 | Feb. 23, 2019 | Zhang, Racke, Smolcic, Atherley | Atlantic 10 Conference Championships |
| 3:22.38 | Feb. 17, 2018 | Fusco, Atherley, Kopydlowski, Zhang | Atlantic 10 Conference Championships |
| 3:23.08 | Feb. 18, 2017 | Fusco, Atherley, Ozturk, Zhang | Atlantic 10 Conference Championships |
| 3:25.07 | Feb. 23, 2013 | Saunders, Fernandez, Saunders, Vanderbilt | Atlantic 10 Conference Championships |
| 3:28.08 | Feb. 26, 2011 | Leor, Saunders, Myers, Saunders | Atlantic 10 Conference Championships |
| 3:32.24 | Nov. 21, 2010 | Saunders, Saunders, Myers, Leor | Patriot Invitational |
| 3:33.26 | Feb. 20, 2010 | Leor, Liedholm, Leik, Timlin | Atlantic 10 Championships |
| 3:36.25 | Nov. 22, 2009 | Timlin, Leik, Beggs, Leor | Patriot Invitational |
| 3:57.64 | Nov. 7, 2009 | Dingess, Mehrtens, Ye | Drexel vs. George Washington, Villanova |
| 4:04.42 | Oct. 24, 2009 | Ye, Jensen, Miesfeld | George Washington vs Georgetown |
