| Time | Date | Name | Meet |
|---|---|---|---|
| 49.17 | Feb. 22, 2019 | Steven Tierney | Patriot League Championships |
| 50.14 | Nov. 17, 2018 | Steven Tierney | Harold Anderson Invitational M |
| 50.94 | Feb. 19, 2016 | Tyler Wright | Patriot League Championships |
| 50.95 | Feb. 20, 2015 | Tyler Wright | Patriot League Championships |
| 51.80 | Feb. 21, 2014 | Tyler Wright | Patriot League Championships |
| 52.25 | Feb. 22, 2013 | Tyler Wright | Patriot League Championships |
| 53.56 | Nov. 17, 2012 | Tyler Wright | Boston Univ Terrier Invitational |
| 53.81 | Feb. 17, 2012 | Michael Brower | Patriot League Championships |
| 54.42 | Jan. 21, 2011 | Michael Noone | Holy Cross vs. Lehigh |
| 55.53 | Feb. 19, 2010 | Nick Larsen | Patriot League Championships |
| 56.47 | Nov. 21, 2008 | Aaron Brosnan | Terrier Invitational |
