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| Time | Date | Name | Team | Meet |
|---|---|---|---|---|
| 21.73 | July 28, 2023 | Jordan Crooks | Cayman Islands Swimming Federation | World Aquatics Championships |
| 22.20 | June 23, 2022 | Jordan Crooks | Cayman Islands Swimming Federation | 19th FINA World Championships |
| 22.54 | Jan. 18, 2020 | Brett Fraser | New York Athletic Club | 54e Challenge International de Geneve |
| 22.65 | July 29, 2011 | Brett Fraser | Cayman Islands Swimming Federation | 14th FINA World Championships |
| 22.80 | July 31, 2009 | Brett Fraser | Cayman Islands Swimming Federation | 13th FINA World Championships |
| 24.43 | Feb. 16, 2008 | Brett Fraser | Missouri Grand Prix | |
| 24.59 | Jan. 26, 2008 | Brett Fraser | University of Florida | Auburn at Florida |