| Name | Time | Date | Meet |
|---|---|---|---|
| Tesla Waters | 52.06 | Feb. 17, 2018 | North Coast Athletic Conference Championships |
| Nora Cooper | 52.75 | Feb. 14, 2015 | 2015 North Coast Athletic Conference Championships |
| Sara Kadi | 53.60 | Feb. 13, 2010 | North Coast Athletic Conference Championships |
| Sara Kadi | 54.64 | Dec. 3, 2009 | Wooster Invitational |
| Sara Kadi | 54.68 | Nov. 13, 2009 | Veale Classic |
| Sara Kadi | 55.15 | Jan. 17, 2009 | John Carroll & Allegheny @Oberlin |
| Jordan Jancosek | 58.70 | Nov. 22, 2008 | Oberlin @ Baldwin-Wallace |
