| Name | Time | Date | Meet |
|---|---|---|---|
| Grace Cooper | 21.66 | Nov. 17, 2023 | Texas Invitational |
| Rebecca Millard | 21.73 | March 16, 2017 | 2017 NCAA Division I Womens Championships |
| Hee-jin Chang | 21.87 | March 12, 2009 | 2009 NCAA Womens Division I Psyche Sheet |
| Hee-jin Chang | 22.05 | Dec. 4, 2008 | 2008 Texas Invitational |
| Hee-jin Chang | 22.39 | March 20, 2008 | 2008 NCAA Division I Womens Championships |
| Connie Brown | 22.68 | March 8, 2007 | 2007 NCAA Division I Womens Championships |
| Tanica Jamison | 23.00 | March 6, 2003 | American Short Course Championships |
